Wednesday, January 23, 2019

Molecular Neuroscience Laboratory


Our lab investigates molecular mechanisms involved in the development of acute and chronic neurodegenerative diseases. Our strategy is primarily based on molecular

biology, however, various kinds of techniques, including cell biological, biochemical, morphological, physiological, and behavioral analyses, are used to decipher the

molecular mechanism. We have access to animal and cell-based models of these diseases, enabling us to investigate the role of specific genes at the whole animal and

cellular levels. Our laboratory studies how hyperglycemia affects the nervous system function, in particular how oxidative stress leads to the degeneration of sensory

neurons and induces neuropathy. Long term goals are to identify new molecular targets for neuroprotective strategies.




Assessing the role of G-protein subunits in the development of diabetic neuropathy and opioid insensitivity in hypeglycemic conditions.

Identification of mechanisms underlying loss of DRG neurons in hyperglycemic conditions.

Determining the subcellular pathways by which some agents protect neurons in hyperglycemic conditions: In vivo and in vitro studies.

We have also been engaging in projects with other various KNRC’s labs.




Saeed Esmaeili Mahani: Director

Manijeh Atapour: Reseach Manager

Zahra Hajalizadeh: Research Assistant

Ayat Kaidi: Msc.Student

Khadijeh Esmaeilpour: Msc.Student